696-06-05,6-dihydro-5-Fluorouracil

产品属性：

Cas No.696-06-0

别名 N/A

化学名 5-fluorodihydro-2,4(1H,3H)-pyrimidinedione

分子式 C4H5FN2O2

分子量 132.1

溶解度 DMF: 60 mg/ml,DMSO: 53 mg/ml,Ethanol: 0.8 mg/ml,PBS (pH 7.2): 8 mg/ml

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD). Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 uM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).