121-61-94-Acetamidobenzenesulfonamide

产品属性：

Cas No.121-61-9

别名 N/A

化学名 N/A

分子式 C8H10N2O3S

分子量 214.2

溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.09 mg/ml

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4-Acetamidobenzenesulfonamide is a metabolite of the herbicide asulam and the sulfonamide antibiotic sulfanilamide .1,2,3 It is formed from asulam by conversion to sulfanilamide via intestinal microflora, followed by N4-acetylation in the liver. 4-Acetamidobenzenesulfonamide inhibits carbonic anhydrase II (CAII), CAIX, and CAXII (Kis = 246, 135, and 49 nM, respectively, for the human enzymes).4 It has also been used in the synthesis of compounds with antibacterial activity.5

1.Heijbroek, W.M., Muggleton, D.F., and Parke, D.V.Metabolism of the carbamate herbicide, asulam, in the ratXenobiotica14(3)235-247(1984) 2.Okumura, F., Ueda, O., Kitamura, S., et al.N-acetylation and N-formylation of carcinogenic arylamines and related compounds in dogsCarcinogenesis16(1)71-76(1995) 3.Olsen, H., and M?rland, J.Sulfonamide acetylation in isolated rat liver cellsActa Pharmacol. Toxicol. (Copenh)49(2)102-109(1981) 4.Ozensoy, O., Puccetti, L., Fasolis, G., et al.Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamidesBioorg. Med. Chem. Lett.15(21)4862-4866(2005) 5.Wang, X.-L., Wan, K., and Zhou, C.-H.Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activitiesEur. J. Med. Chem.45(10)4631-4639(2010)