53818-10-34’-hydroxy Trazodone

产品属性：

Cas No.53818-10-3

别名 N/A

化学名 N/A

分子式 C19H22ClN5O2

分子量 387.9

溶解度 Chloroform: slightly soluble,Methanol: slightly, sonicated

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1 It is an inhibitor of organic anion transporter 3 (OAT3; Ki = 16.9 μM) and is selective for OAT3 over OAT1 (Ki = >200 μM).2

1.Yamato, C., Takahashi, T., Fujita, T., et al.Studies on metabolism of trazodone, II. Metabolic fate after intravenous administration and effects on liver microsomal drug-metabolizing enzymes in ratsXenobiotica4(12)765-777(1974) 2.Zou, L., Matsson, P., Stecula, A., et al.Drug metabolites potently inhibit renal organic anion transporters, OAT1 and OAT3J. Pharm. Sci.110(1)347-353(2021)