6481-48-71-Methylhistamine (hydrochloride)

产品属性：

Cas No.6481-48-7

别名 N/A

化学名 1-methyl-H-imidazole-4-ethanamine, dihydrochloride

分子式 C6H11N3?2HCl

分子量 198.1

溶解度 1mg/mL in ethanol, 20mg/mL in DMSO

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
1-Methylhistamine is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism.[1] It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer’s disease patients as well as those with hypersomnia and other neurological conditions.[2] [3]

Reference:

[1]. Lindell, S.E., and Schayer, R.W. Metabolism of injected [14C] histamine in the kidney of the dog. Br.J.Pharmacol.Chemother. 13(1), 52-53 (1958).

[2]. Motawaj, M., Peoc'h, K., Callebert, J., et al. CSF levels of the histamine metabolite tele-methylhistamine are only slightly decreased in Alzheimer’s disease. J.Alzheimers Dis. 22(3), 861-871 (2010).

[3]. Dauvilliers, Y., Delallée, N., Jaussent, I., et al. Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions. Sleep 35(10), 1359-1366 (2016).