139408-39-213(S)-HODE-d4

产品属性：

Cas No.139408-39-2

别名 N/A

化学名 N/A

分子式 C18H28D4O3

分子量 300.5

溶解度 DMF: >50 mg/ml (per Rao Maddipati),DMSO: >50 mg/ml (per Rao Maddipati),Ethanol: >50 mg/ml (per Rao Maddipati),PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)

储存条件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-mass spectrometry. 13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 μM,1,2 and down regulates the expression of the IRGpIIb/IIIa receptor.3

1.Buchanan, M.R., Haas, T.A., Lagarde, M., et al.13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOXThe Journal of Biological Chemisty26016056-16059(1985) 2.Honn, K.V., Nelson, K.K., Renaud, C., et al.Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasisProstaglandins44(5)413-429(1992) 3.Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al.Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acidCancer Res.49(4)1029-1037(1989)