820240-77-5 AUY954

产品属性：

Cas No. 820240-77-5

别名 N/A

化学名 N/A

Canonical SMILES OC(CCNCC1=CC=C2C(C=C(C3=CC(C(F)(F)F)=C(C4=CC=CC=C4)C=C3)S2)=C1)=O

分子式 C25H20F3NO2S

分子量 455.5

溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存条件 Store at -20°C

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

产品描述：
AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.