中文名称

血苷|唾液酸乳糖苷神经酰胺；神经节苷脂GM3，一钠盐

英文名字

Hematoside|Sialosyllactosylceramide; Ganglioside GM3, monosodium salt

供应商

开曼生物

产品货号

15587-1

背景资料

Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cell signaling events. Gangliosides are often implicated in tumorigenesis since they can modulate cell surface events including proliferation, migration, and adhesion. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. At 20 μM, it can suppress angiogenesis and reduce endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.{25490,25485} Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.{25481}

产品描述

A monosialoganglioside that demonstrates both antiproliferative and antiangiogenic effects in tumor cells; dissociates the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance

保存建议

建议您在收到开曼生物品牌的Ganglioside GM3 (sodium salt) (1 mg)产品后置于-20度保存，产品有效期为730天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.