人β2微球蛋白

中文名称

【B2M】人β2微球蛋白

英文名字

Human Beta 2 Microglobulin

供应商

ProSpec

产品货号

PRO-553

背景资料

?2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. ?2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of ?2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I.
Beta 2-microglobulin is present in small amounts in serum， csf， and urine of normal people， and to a much greater degree in the urine and plasma of patients with tubular proteinaemia， renal failure， or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased （e.g. in AIDS， malignant monoclonal plasma cell dyscrasia， solid tumors and autoimmune disease） or because of impaired renal filtration （e.g. due to renal insufficiency， graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy）. Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis， it can aggregate into amyloid fibers that deposit in joint spaces.

序列

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来源宿主

患有肾小管性蛋白尿病患者的尿液中提取纯化

溶解建议

Sterile Filtered White lyophilized （freeze-dried） powder. Lyophilized from 0.02M NH4HCO3. It is recommended to reconstitute the lyophilized HuB2M in phosphate buffer pH > 7.0 containing 0.15M NaCl.

保存建议

Human B2M although stable at room temperature for 3 weeks， should be stored between 2-8℃.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。