中文名称

D，L-C16-二氢鞘氨醇（混合异构体）

英文名字

D,L-C16-Dihydrosphingosine (mixed isomers)

供应商

Matreya

产品货号

1326-10

背景资料

This dihydrosphingosine standard is a mixture of D and L isomers and contains approximately 90% erythro and 10% threo isomers. It is a 16 carbon chain, two carbons shorter than the most prevalent dihydrosphingosine in most animals. However, some animals, such as Drosophila melanogaster, have the shorter C16 dihydrosphingosine base.1 Dihydrosphingosine (Sphinganine) is the precursor of dihydroceramide which is then desaturated to form ceramide. It is a critical intermediate in the synthesis of many complex sphingoid bases and ceramide analogs. It has been found that sphinganine can induce cell death in a number of types of malignant cells and is being tested for its pharmacological properties.2 Inhibition of dihydroceramide synthesis by some fungal toxins that have a similar structure causes an increase in sphinganine and sphinganine-1-phosphate and a decrease in other sphingolipids leading to a number of diseases including oesophageal cancer.3 Sphinganine has been found to mediate fumonisin (a toxic sphinganine analog) induced hypotension.4

产品描述

D,L-Sphinganine,C16 chain

产品形式

该D，L-C16-二氢鞘氨醇（混合异构体）产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。