安丝菌素

通用名称: 安丝菌素P-3 (束丝放线菌、安沙菌素) 英文名称: Ansamitocin P-3 Synonyms: 3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine butyrate (ester); Antibiotic C 15003P3 Molecular Formula: C32H43ClN2O9 Molecular Weight: 635.14 CAS No.: 66547-09-9 【项目简介】 Ansamitocin P-3 is a maytansine analog which displays potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. It shares the same binding site as rhizoxin and phomopsin A on porcine brain tubulin. Maytansine and its analogs cause extensive disassembly of the microtubule and totally prevent tubulin spiralization.