AER-271

Description: AER-271 is a potent aquaporin-4 (AQP4) inhibitor. AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest. Treatment with AER-271 ameliorated early cerebral edema measured at 3 h after CA vs vehicle treated rats. This treatment also attenuated early NDS. In contrast to rats treated with vehicle after CA, rats treated with AER-271 did not develop significant neuronal death or neuroinflammation as compared to sham.

Name: AER-271
CAS#: 634913-39-6
Chemical Formula: C15H9ClF6NO5P
Exact Mass: 462.9811
Molecular Weight: 463.6532
Elemental Analysis: C, 38.86; H, 1.96; Cl, 7.65; F, 24.59; N, 3.02; O, 17.25; P, 6.68

IUPAC/Chemical Name: 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate

InChi Key: WSHXPHFIHYXZKC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9ClF6NO5P/c16-9-1-2-12(28-29(25,26)27)11(6-9)13(24)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6H,(H,23,24)(H2,25,26,27)

SMILES Code: O=P(O)(OC1=CC=C(Cl)C=C1C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)O

Appearance: Solid powder