A2AR agonist-1

Name: A2AR agonist-1
CAS#: 41552-95-8
Chemical Formula: C20H22N6O4
Exact Mass: 410.1703
Molecular Weight: 410.43
Elemental Analysis: C, 58.53; H, 5.40; N, 20.48; O, 15.59

Description: A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1). A2AR agonist-1 also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease.

IUPAC/Chemical Name: N-[2-(1H-indol-3-yl)ethyl]-adenosine

InChi Key: QGCNEMXXKWZPHR-WVSUBDOOSA-N

InChi Code: InChI=1S/C20H22N6O4/c27-8-14-16(28)17(29)20(30-14)26-10-25-15-18(23-9-24-19(15)26)21-6-5-11-7-22-13-4-2-1-3-12(11)13/h1-4,7,9-10,14,16-17,20,22,27-29H,5-6,8H2,(H,21,23,24)/t14-,16-,17-,20-/m1/s1

SMILES Code: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NCCC4=CNC5=C4C=CC=C5)N=CN=C32

Appearance: Solid powder