β淀粉样肽1-40/β-Amyloid（1-40）/131438-79-4

Product Name:β-Amyloid（1-40）   

Synonyms:β-Amyloid（1-40）,Ultra Pure TFA

CAS No.: 131438-79-4

Catalog No.:GT-F048

Key Specification:

Appearance:  White powder
Purity (HPLC) ≥95.0%

Single impurity≤1.5%

Peptide content≥70.0%

Amino Acid Composition≤±10%

Package:

Vacuum-packed with aluminum foil bag or transparent bag. 10mg,50mg, 100mg,1g,10g, 50g per package with icebag. Or according to your request. 

Description:

阿尔茨海默病（AD）是一种起病隐匿的进行性发展的神经系统退行性疾病。临床上以记忆障碍、失语、失用、失认、视空间技能损害、执行功能障碍以及人格和行为改变等全面性痴呆表现为特征。

流行病学研究表明，非甾体抗炎药(环氧合酶抑制剂)可预防或延缓阿尔茨海默病的发病，提示脑炎症在临床症状出现之前就促进了疾病进展。

β-淀粉样蛋白和细胞因子能促使炎性小神经胶质细胞激活，此过程会释放过氧化氢、TNF-α 和 IL-1β杀伤因子。过氧化氢能促进小神经胶质细胞的增殖，TNF-α（肿瘤坏死因子） 和 IL-1β（白细胞介素）是非常强力的生物活性因子，能迅速杀死病变的神经元。并且被激活后的炎性小神经胶质细胞会长期存在于阿尔茨海默病患者的神经炎斑块中。

实验发现，β-淀粉样蛋白、细胞因子和被激活的小胶质细胞能够强力的杀死共培养的神经元，相比β-Amyloid（1-42），β-Amyloid（1-40）有着更好的水溶性。所以，把小神经胶质细胞激活并促使其杀死病变的神经元，可能是治疗此类疾病的最终手段。

Alzheimer's disease (AD) is a progressive and degenerative disease of the nervous system that begins insidiously. It is clinically characterized by comprehensive dementia manifestations such as memory impairment, aphasia, apraxia, loss of recognition, impaired visual space skills, executive dysfunction, and personality and behavior changes. Epidemiological studies have shown that non-steroidal anti-inflammatory drugs (cyclooxygenase inhibitors) can prevent or delay the onset of Alzheimer's disease, suggesting that brain inflammation promotes disease progression before clinical symptoms appear.

β-amyloid protein and cytokines can promote the activation of inflammatory microglia cells, this process will release hydrogen peroxide, TNF-α and IL-1β killing factors. Hydrogen peroxide can promote the proliferation of microglial cells. TNF-α (tumor necrosis factor) and IL-1β (interleukin) are very powerful biologically active factors that can quickly kill diseased neurons. And the activated inflammatory microglia will exist in the neuritic plaques of Alzheimer's disease patients for a long time. The experiment found that β-amyloid, cytokines and activated microglia can strongly kill co-cultured neurons. Compared with β-Amyloid (1-42), β-Amyloid (1-40) has Better water solubility. Therefore, activating microglial cells and prompting them to kill the diseased neurons may be the ultimate treatment for such diseases.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

Spec.:

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