OATD-01

Name: OATD-01
CAS#: 2088453-21-6
Chemical Formula: C19H27ClN6O
Exact Mass: 390.1935
Molecular Weight: 390.92
Elemental Analysis: C, 58.38; H, 6.96; Cl, 9.07; N, 21.50; O, 4.09

Description: OATD-01, also known as GLPG 4716, is a potent and selective chitinase inhibitor for treatment of interstitial lung diseases. OATD-01 showed (hAMCase IC50=9nM, hCHIT1 IC50=26nM) significantly reduced lung fibrosis in the bleomycin-induced fibrosis model, comparably to nintedanib, as assessed by modified Ashcroft scoring. The anti-fibrotic activity of OATD-01 was associated with pharmacodynamic effect: plasma chitinolytic activity was significantly reduced in mice dosed with OATD-01 as compared to control group.

IUPAC/Chemical Name: 5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine

InChi Key: STWVLEKJQQRGMO-GUYCJALGSA-N

InChi Code: InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1

SMILES Code: C[C@H]1CN(C2CCN(C3=NN=C(N)N3)CC2)[C@@H](CC4=CC=C(Cl)C=C4)CO1

Appearance: Solid powder