SJF-8240

Name: SJF-8240
CAS#: 2230821-68-6
Chemical Formula: C58H65F2N7O11S
Exact Mass: 1105.4431
Molecular Weight: 1106.2528
Elemental Analysis: C, 62.97; H, 5.92; F, 3.43; N, 8.86; O, 15.91; S, 2.90

Description: SJF-8240 is a c-MET degrader. It comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. SJF-8240 degrades c-MET within 6 hours in vitro and inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation. It also degrades exon-14-deleted c-MET in Hs746T cells.

IUPAC/Chemical Name: N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

InChi Key: MCJFROJTDORRBB-ZWUDBOSPSA-N

InChi Code: InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-64-35)37-10-8-36(9-11-37)32-63-53(70)45-29-41(68)33-66(45)54(71)52(57(2,3)4)65-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-62-44)78-47-17-16-40(28-43(47)60)67(39-14-12-38(59)13-15-39)56(73)58(20-21-58)55(61)72/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H2,61,72)(H,63,70)(H,65,69)/t41-,45+,52-/m1/s1

SMILES Code: O=C(C1(C(N)=O)CC1)N(C2=CC=C(OC3=CC=NC4=CC(OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C(OC)C=C34)C(F)=C2)C8=CC=C(F)C=C8

Appearance: Solid powder