PF-04671536

Name: PF-04671536
CAS#: 1305116-69-1
Chemical Formula: C14H18N8OS
Exact Mass: 346.1324
Molecular Weight: 346.413
Elemental Analysis: C, 48.54; H, 5.24; N, 32.35; O, 4.62; S, 9.25

Description: PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.

IUPAC/Chemical Name: 5-Methyl-3-[[(2R)-4 (2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine

InChi Key: QGTJGTFOISKMAD-SNVBAGLBSA-N

InChi Code: InChI=1S/C14H18N8OS/c1-9-17-13(15)12-14(18-9)22(20-19-12)7-10-6-21(3-4-23-10)8-11-16-2-5-24-11/h2,5,10H,3-4,6-8H2,1H3,(H2,15,17,18)/t10-/m1/s1

SMILES Code: NC1=C(N=NN2C[C@H]3CN(CC4=NC=CS4)CCO3)C2=NC(C)=N1

Appearance: Solid powder