XY 018

Name: XY 018
CAS#: 1873358-87-2
Chemical Formula: C23H15F7N2O4
Exact Mass: 516.092
Molecular Weight: 516.3718
Elemental Analysis: C, 53.50; H, 2.93; F, 25.75; N, 5.43; O, 12.39

Description: XY 018 is a RORγ antagonist that suppresses androgen receptor expression in prostate cancer cell lines and inhibits growth of tumors in androgen receptor-positive xenograft models.

IUPAC/Chemical Name: N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide

InChi Key: MNVXADPCMINSEC-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H15F7N2O4/c24-18-12-15(21(34,22(25,26)27)23(28,29)30)7-10-17(18)13-5-8-16(9-6-13)31-20(33)11-14-3-1-2-4-19(14)32(35)36/h1-10,12,34H,11H2,(H,31,33)

SMILES Code: O=C(NC1=CC=C(C2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2F)C=C1)CC3=CC=CC=C3[N+]([O-])=O

Appearance: Solid powder