T-5342126

Name: T-5342126
CAS#: 956507-49-6
Chemical Formula: C25H32ClN3O3
Exact Mass: 457.2132
Molecular Weight: 457.999
Elemental Analysis: C, 65.56; H, 7.04; Cl, 7.74; N, 9.17; O, 10.48

Description: T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 µM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

IUPAC/Chemical Name: 1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-ethoxyphenoxy)propan-2-ol

InChi Key: UOKIJOWYTBNPIM-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H32ClN3O3/c1-5-31-22-10-12-23(13-11-22)32-17-21(30)15-28(4)16-24-18(2)27-29(19(24)3)14-20-8-6-7-9-25(20)26/h6-13,21,30H,5,14-17H2,1-4H3

SMILES Code: CN(CC1=C(N(N=C1C)CC2=CC=CC=C2Cl)C)CC(O)COC3=CC=C(OCC)C=C3

Appearance: Solid powder