PFM39

Name: PFM39
CAS#: 1310744-67-2
Chemical Formula: C10H9N3OS
Exact Mass: 219.0466
Molecular Weight: 219.262
Elemental Analysis: C, 54.78; H, 4.14; N, 19.16; O, 7.30; S, 14.62

Description: PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

IUPAC/Chemical Name: (5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone

InChi Key: QXOIZYPBCJHYLN-YVMONPNESA-N

InChi Code: InChI=1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5-

SMILES Code: O=C1N=C(N)S/C1=C\C2=CC=C(N)C=C2

Appearance: Solid powder