Sekikaic Acid

Name: Sekikaic Acid
CAS#: 607-11-4
Chemical Formula: C22H26O8
Exact Mass: 418.1628
Molecular Weight: 418.442
Elemental Analysis: C, 63.15; H, 6.26; O, 30.59

Description: Sekikaic acid is a phenolic lichen metabolite that has been found in H. obscurata and has diverse biological activities. It scavenges superoxide and DPPH radicals in cell-free assays when used at a concentration of 0.5 µM. Sekikaic acid is active against the rg recombinant strain of respiratory syncytial virus (RSV; IC50 = 5.69 µg/ml). It inhibits the protein-protein interaction between mixed lineage leukemia 1 (MLL1) and the GACKIX domain of CREB-binding protein (CBP; IC50 = 34 µM).

IUPAC/Chemical Name: 2-hydroxy-3-((2-hydroxy-4-methoxy-6-propylbenzoyl)oxy)-4-methoxy-6-propylbenzoic acid

InChi Key: CPHXGYQLOSNELY-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H26O8/c1-5-7-12-9-14(28-3)11-15(23)17(12)22(27)30-20-16(29-4)10-13(8-6-2)18(19(20)24)21(25)26/h9-11,23-24H,5-8H2,1-4H3,(H,25,26)

SMILES Code: COC1=CC(CCC)=C(C(O)=C1)C(OC2=C(C=C(C(C(O)=O)=C2O)CCC)OC)=O

Appearance: Solid powder