PF-06648671

Name: PF-06648671
CAS#: 1587727-31-8
Chemical Formula: C25H23ClF4N4O3
Exact Mass: 538.1395
Molecular Weight: 538.92
Elemental Analysis: C, 55.72; H, 4.30; Cl, 6.58; F, 14.10; N, 10.40; O, 8.91

Description: PF-06648671 is a γ-secretase modulator or Amyloid precursor protein secretase modulator for the treatment of neurodegenerative and/or neurological disorders such as Alzheimer’s disease and Down’s Syndrome. PF-06648671 decreased Aβ42 and Aβ40 concentrations in CSF, with greater effects on Aβ42, and increased Aβ37 and Aβ38 levels, particularly Aβ37. No significant change in total Aβ was observed. PF-06648671 resulted in robust, dose-dependent reductions in CSF Aβ42 and Aβ40 and elevations in Aβ37 and Aβ38, with no effect on total Aβ.

IUPAC/Chemical Name: 2-[(1S)-1-[(2S,5R)-5-[4-Chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-2H-pyrido[1,2-a]pyrazine-1,6-dione

InChi Key: AKCDDYGYIGPEKL-JQOQJDEVSA-N

InChi Code: InChI=1S/C25H23ClF4N4O3/c1-13-11-32(12-31-13)19-3-4-20-24(36)33(7-8-34(20)23(19)35)14(2)21-5-6-22(37-21)15-9-18(27)17(26)10-16(15)25(28,29)30/h3-4,9-12,14,21-22H,5-8H2,1-2H3/t14-,21-,22+/m0/s1

SMILES Code: O=C1C(N2CCN1[C@H]([C@H]3O[C@@H](C4=CC(F)=C(Cl)C=C4C(F)(F)F)CC3)C)=CC=C(N5C=C(C)N=C5)C2=O

Appearance: Solid powder