PBOX-15

Name: PBOX-15
CAS#: 354759-10-7
Chemical Formula: C28H19NO3
Exact Mass: 417.1365
Molecular Weight: 417.464
Elemental Analysis: C, 80.56; H, 4.59; N, 3.36; O, 11.50\

Description: PBOX-15 is a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin. PBOX-15 induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.

IUPAC/Chemical Name: 5-(naphthalen-1-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate

InChi Key: STVDRIIZTGYIMM-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H19NO3/c1-18(30)31-28-24-14-7-15-29(24)25-16-20-9-2-3-10-21(20)17-26(25)32-27(28)23-13-6-11-19-8-4-5-12-22(19)23/h2-17H,1H3

SMILES Code: CC(OC1=C(C2=C3C=CC=CC3=CC=C2)OC4=CC5=CC=CC=C5C=C4N6C1=CC=C6)=O

Appearance: Solid powder