TAS 205

Name: TAS 205
CAS#: 1584160-52-0
Chemical Formula: C27H38N6O5
Exact Mass: 526.2904
Molecular Weight: 526.638
Elemental Analysis: C, 61.58; H, 7.27; N, 15.96; O, 15.19

Description: TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 55.8 nM). It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 µM, as well as over enzyme and receptor panels at 10 µM. TAS 205 inhibits production of prostaglandin D2 (PGD2) induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50 values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg.

IUPAC/Chemical Name: 4-(1-methyl-1H-pyrrole-2-carbonyl)-N-(4-(4-(morpholine-4-carbonyl)piperidin-1-yl)phenyl)piperazine-1-carboxamide hydrate

InChi Key: NFXCKTKGAJDCBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H36N6O4.H2O/c1-29-10-2-3-24(29)26(35)31-13-15-33(16-14-31)27(36)28-22-4-6-23(7-5-22)30-11-8-21(9-12-30)25(34)32-17-19-37-20-18-32;/h2-7,10,21H,8-9,11-20H2,1H3,(H,28,36);1H2

SMILES Code: O=C(NC1=CC=C(C=C1)N2CCC(C(N3CCOCC3)=O)CC2)N4CCN(C(C5=CC=CN5C)=O)CC4.O

Appearance: Solid powder