V-11-0711

Name: V-11-0711
CAS#: 1428339-47-2
Chemical Formula: C27H35NO3
Exact Mass: 421.2617
Molecular Weight: 421.581
Elemental Analysis: C, 76.92; H, 8.37; N, 3.32; O, 11.39

Description: V-11-0711 is a Chk-α inhibitor. V-11-0711 reduced the function of Chk-α by binding to the active site and inhibiting the catalytic activity but did not affect Chk-α protein levels. Chk-α protein and PtdCho, but not PC, may be essential in cancer cell proliferation.

IUPAC/Chemical Name: (1S)-1-phenyl-1-((1R,4R)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol

InChi Key: XPPGCUMGAQHVOY-ZCJYOONXSA-N

InChi Code: InChI=1S/C27H35NO3/c29-27(23-7-2-1-3-8-23,25-20-28-16-11-21(25)12-17-28)15-10-22-6-4-5-9-26(22)31-24-13-18-30-19-14-24/h1-9,21,24-25,29H,10-20H2/t25?,27-/m1/s1

SMILES Code: OC(C1C[N@]2CC[C@]1([H])CC2)(C3=CC=CC=C3)CCC4=CC=CC=C4OC5CCOCC5

Appearance: Solid powder