PF-06761281

Name: PF-06761281
CAS#: 1854061-19-0
Chemical Formula: C13H17NO6
Exact Mass: 283.1056
Molecular Weight: 283.28
Elemental Analysis: C, 55.12; H, 6.05; N, 4.94; O, 33.89

Description: PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.

IUPAC/Chemical Name: (2R)-2-Hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-butanedioic acid

InChi Key: FGYMJXFSHBLHLW-CYBMUJFWSA-N

InChi Code: InChI=1S/C13H17NO6/c1-8-5-9(11(20-2)14-7-8)3-4-13(19,12(17)18)6-10(15)16/h5,7,19H,3-4,6H2,1-2H3,(H,15,16)(H,17,18)/t13-/m1/s1

SMILES Code: O=C(O)[C@](CCC1=CC(C)=CN=C1OC)(O)CC(O)=O

Appearance: Solid powder