KVA-D-88

Name: KVA-D-88
CAS#: 2410550-31-9
Chemical Formula: C17H11Cl2F2N3O
Exact Mass: 381.0247
Molecular Weight: 382.1918
Elemental Analysis: C, 53.43; H, 2.90; Cl, 18.55; F, 9.94; N, 10.99; O, 4.19

Description: KVA-D-88 is an inhibitor of phosphodiesterase 4B (PDE4B). It is selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 µM but does inhibit the activity of PDE4C1, PDE3B, the serotonin receptor subtype 5-HT2C, and sigma-2 (σ2) receptors by greater than 50%. KVA-D-88 decreases LPS- or Pam3Cys-induced production of TNF-α in mouse bone marrow-derived macrophages. It reduces cocaine self-administration and the progressive ratio breakpoint in mice when administered at a dose of 5 mg/kg.

IUPAC/Chemical Name: (1-(3,4-Dichlorophenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)(3,3-difluoroazetidin-1-yl)methanone

InChi Key: JQEUSIGJVMRCOL-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H11Cl2F2N3O/c18-12-4-3-11(7-13(12)19)24-14(6-10-2-1-5-22-15(10)24)16(25)23-8-17(20,21)9-23/h1-7H,8-9H2

SMILES Code: O=C(C1=CC2=CC=CN=C2N1C3=CC=C(Cl)C(Cl)=C3)N4CC(F)(F)C4

Appearance: Solid powder