JR-AB2-011

Name: JR-AB2-011
CAS#: 2411853-34-2
Chemical Formula: C17H14Cl2FN3OS
Exact Mass: 397.0219
Molecular Weight: 398.27
Elemental Analysis: C, 51.27; H, 3.54; Cl, 17.80; F, 4.77; N, 10.55; O, 4.02; S, 8.05

Description: JR-AB2-011 is a potent and selective inhibitor of mTORC2 kinase activity. It markedly reduces mTORC2 signaling and IC50 while enhancing apoptotic levels in GBM cells. 

IUPAC/Chemical Name: (Z)-N-(3,4-dichlorophenyl)-2-((4-fluorophenyl)imino)-5-methylthiazolidine-3-carboxamide

InChi Key: TWTNZYABDOSOSR-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H14Cl2FN3OS/c1-10-9-21-17(25-10)23(13-5-2-11(20)3-6-13)16(24)22-12-4-7-14(18)15(19)8-12/h2-8,10H,9H2,1H3,(H,22,24)

SMILES Code: ClC1=C(Cl)C=C(NC(N2/C(SC(C)C2)=N/C3=CC=C(F)C=C3)=O)C=C1

Appearance: Solid powder