Moexipril-d5

Name: Moexipril-d5
CAS#: 1356929-49-1
Chemical Formula: C27H29D5N2O7
Exact Mass: 503.268
Molecular Weight: 503.6065
Elemental Analysis: C, 64.39; H, 7.80; N, 5.56; O, 22.24

Description: Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.1 It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.

IUPAC/Chemical Name: (S)-2-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)-L-alanyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

InChi Key: UWWDHYUMIORJTA-SBCWFVTISA-N

InChi Code: InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1/i6D,7D,8D,9D,10D

SMILES Code: [2H]C1=C(C([2H])=C(C([2H])=C1CC[C@H](N[C@H](C(N2CC3=CC(OC)=C(C=C3C[C@H]2C(O)=O)OC)=O)C)C(OCC)=O)[2H])[2H]

Appearance: Solid powder