K67

Name: K67
CAS#: 2046250-48-8
Chemical Formula: C29H30N2O7S2
Exact Mass: 582.1494
Molecular Weight: 582.68
Elemental Analysis: C, 59.78; H, 5.19; N, 4.81; O, 19.22; S, 11.00

Description: K67 is a specific inhibitor against the interaction between KEAP1 DC domain and S349-phosphorylated KIR of p62/SQSTM1, K67 effectively inhibits the proliferation of HCC cultures with high cellular p62 S351-phosphorylation by restoring KEAP1-driven NRF2 ubiquitination and degradation.

IUPAC/Chemical Name: 2-Acetonyl-1,4-bis[(4-ethoxybenzensulfonyl)amino]naphthalene

InChi Key: VUIVGOOWLHGDPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H30N2O7S2/c1-4-37-22-10-14-24(15-11-22)39(33,34)30-28-19-21(18-20(3)32)29(27-9-7-6-8-26(27)28)31-40(35,36)25-16-12-23(13-17-25)38-5-2/h6-17,19,30-31H,4-5,18H2,1-3H3

SMILES Code: O=S(NC1=C2C=CC=CC2=C(NS(=O)(C3=CC=C(OCC)C=C3)=O)C(CC(C)=O)=C1)(C4=CC=C(OCC)C=C4)=O

Appearance: Solid powder