ML 252

Name: ML 252
CAS#: 1392494-64-2
Chemical Formula: C20H24N2O
Exact Mass: 308.1889
Molecular Weight: 308.425
Elemental Analysis: C, 77.89; H, 7.84; N, 9.08; O, 5.19

Description: ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays >40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 μM for KV7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of >68 GPCRs, ion channels and transporters. It inhibits melatonin MT1 receptor 60% at 10 μM. ML 252 is brain penetrant.

IUPAC/Chemical Name: (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide

InChi Key: FROGGFONBYACJB-KRWDZBQOSA-N

InChi Code: InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1

SMILES Code: O=C(NC1=C(C=CC=C1)N2CCCC2)[C@H](C3=CC=CC=C3)CC

Appearance: Solid powder