Fenobam hydrate

Name: Fenobam hydrate
CAS#: 63540-28-3
Chemical Formula: C11H13ClN4O3
Exact Mass: 284.0676
Molecular Weight: 284.7
Elemental Analysis: C, 46.41; H, 4.60; Cl, 12.45; N, 19.68; O, 16.86

Description: Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits basal activity of mGluR5. Fenobam reduces stress-induced hyperthermia, exhibits anxiolytic-like activity, and may induce analgesia.

IUPAC/Chemical Name: N-(3-chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-urea, monohydrate

InChi Key: UNFQKKSADLVQJE-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H11ClN4O2.H2O/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8;/h2-5H,6H2,1H3,(H2,13,14,15,17,18);1H2

SMILES Code: ClC1=CC=CC(NC(NC(N(C)C2)=NC2=O)=O)=C1.O

Appearance: Solid powder