IMP-1710

Name: IMP-1710
CAS#: 2383117-96-0
Chemical Formula: C23H19N5O
Exact Mass: 381.159
Molecular Weight: 381.439
Elemental Analysis: C, 72.42; H, 5.02; N, 18.36; O, 4.19

Description: IMP-1710 is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) that contains an alkyne moiety for use in click chemistry reactions. It is selective for UCH-L1 over a panel of 20 deubiquitinating enzymes at 1 µM. IMP-1710 inhibits TGF-β1-induced fibroblast-to-myofibroblast transition (FMT) in primary lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis (IC50 = 740 nM). It has been used for labeling UCH-L1 in cell-based assays, followed by click reactions with azide-modified TAMRA and biotin capture reagents.

IUPAC/Chemical Name: (S)-2-(4-(5-ethynyl-1H-pyrrolo[2,3-b]pyridin-3-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile

InChi Key: FYMVGXGSNIVSKY-NRFANRHFSA-N

InChi Code: InChI=1S/C23H19N5O/c1-2-15-11-18-19(13-26-22(18)25-12-15)16-5-3-6-20-17(16)8-10-28(20)23(29)21-7-4-9-27(21)14-24/h1,3,5-6,11-13,21H,4,7-10H2,(H,25,26)/t21-/m0/s1

SMILES Code: O=C(N1C2=CC=CC(C3=CNC4=NC=C(C#C)C=C34)=C2CC1)[C@H]5N(CCC5)C#N

Appearance: Solid powder