LH1306

Name: LH1306
CAS#: 2182653-84-3
Chemical Formula: C38H48N6O6
Exact Mass: 684.3635
Molecular Weight: 684.84
Elemental Analysis: C, 66.65; H, 7.07; N, 12.27; O, 14.02

Description: LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1. It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1.

IUPAC/Chemical Name: N,N′-[(2,2′-dimethyl[1,1′-biphenyl]-3,3′-diyl)bis[methyleneoxy(6-methoxy-2,5-pyridinediyl)methyleneimino-2,1-ethanediyl]]bis-acetamide

InChi Key: ZNRITEYTYHQVTF-UHFFFAOYSA-N

InChi Code: InChI=1S/C38H48N6O6/c1-25-31(23-49-35-15-13-29(37(43-35)47-5)21-39-17-19-41-27(3)45)9-7-11-33(25)34-12-8-10-32(26(34)2)24-50-36-16-14-30(38(44-36)48-6)22-40-18-20-42-28(4)46/h7-16,39-40H,17-24H2,1-6H3,(H,41,45)(H,42,46)

SMILES Code: CC1=C(COC2=CC=C(CNCCNC(C)=O)C(OC)=N2)C=CC=C1C3=C(C)C(COC4=NC(OC)=C(CNCCNC(C)=O)C=C4)=CC=C3

Appearance: Solid powder