BMP-22

Name: BMP-22
CAS#: 1306684-90-1
Chemical Formula: C22H39O3P
Exact Mass: 382.2637
Molecular Weight: 382.52
Elemental Analysis: C, 69.08; H, 10.28; O, 12.55; P, 8.10

Description: BMP-22 is an inhibitor of autotaxin. It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7. BMP-22 inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC) and inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.

IUPAC/Chemical Name: p-[(4-pentadecylphenyl)methyl]-phosphonic acid

InChi Key: XWVBRTAQHMKHCE-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H39O3P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21-16-18-22(19-17-21)20-26(23,24)25/h16-19H,2-15,20H2,1H3,(H2,23,24,25)

SMILES Code: OP(CC1=CC=C(CCCCCCCCCCCCCCC)C=C1)(O)=O

Appearance: Solid powder