肝星状细胞(Hepatic Stellate Cells)
肝星状细胞(Hepatic Stellate Cells) 是各种致纤维化因素的最终靶细胞,正常情况下肝星状细胞处于静止状态,当肝脏受到炎症或机械刺激等损伤时,肝星状细胞被激活,其表型由静止型转变为激活型。
应用方向:
1)HSC与肝纤维化
2)HSC与肝脏发育和再生
3)HSC与肝肿瘤
4)HSC与免疫系统
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2016-2019 论文引用(部分):
Deng M, Xu L, Xie X et al., .Downregulation of syndecan‑1 expression induces activation of hepatic stellate cells via the TGF‑β1/Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74.
Zhang F, Lu S, He J et al., Ligand activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26.
Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726.
Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96.
He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43.
Zhang F, Lu C, Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6.
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