Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine， the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 ug/ml. fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%， respectively， using 5 uM oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions. Oleic acid， whether applied extracellularly （EC50 = ~60 uM） to human platelets or released from membrane phospholipids， causes an increase in intracellular calcium levels.
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Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine， the major phospholipid class in porcine platelets.{3964} Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 ug/ml.{3964} fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%， respectively， using 5 uM oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions.{2095} Oleic acid， whether applied extracellularly （EC50 = ~60 uM） to human platelets or released from membrane phospholipids， causes an increase in intracellular calcium levels.{4198}
