5-（4-氯苯基）-1-（4-甲氧基苯基）-3-（三氟甲基）-1H-吡唑； SC-560

中文名称

5-（4-氯苯基）-1-（4-甲氧基苯基）-3-（三氟甲基）-1H-吡唑； SC-560

英文名字

5-（4-chlorophenyl）-1-（4-methoxyphenyl）-3-（trifluoromethyl）-1H-pyrazole； SC-560

供应商

开曼生物

产品货号

70340-1

产品报价

￥231/1mg

产品说明书

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购买方式

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产品新闻

背景资料

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase （COX） inhibitors which includes celecoxib （Celebrex™） and rofecoxib （Vioxx™）. However， unlike these selective COX-2 inhibitors， SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes， the IC50 value for SC-560 with respect to COX-1 is 9 nM， while the corresponding IC50 value for COX-2 is 6.3 uM. Thus， SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat， where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However， SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model， in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells， however， SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.

产品描述

SC-560 is a member of the diaryl heterocycle class of COX inhibitors which includes celecoxib （Celebrex™） and rofecoxib （Vioxx™）. However， unlike these selective COX-2 inhibitors， SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes， the IC50 value for SC-560 with respect to COX-1 is 9 nM， while the corresponding IC50 value for COX-2 is 6.3 uM.{7675} Thus， SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat， where 10 mg/kg completely abolishes the ionophore-induced production of TXB2 in whole blood. However， SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model， in which the COX-2 generated prostaglandins play a significant role in the inflammatory process.{1282} In whole cells， however， SC-560 appears to act as a non-selective COX inhibitor.{14472} The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.

保存建议

建议您在收到开曼生物品牌的SC-560 （1 mg）产品后置于-20度保存，产品有效期为730天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.