INT-777

中文名称

INT-777

英文名字

INT-777

供应商

开曼生物

产品货号

17678-500

产品报价

￥1601.6/500ug

产品说明书

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购买方式

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产品新闻

背景资料

TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid.{29321} INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 µM).{17880,29490} It is active in vivo, stimulating the secretion of glucagon-like peptide-1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a dipeptidyl-peptidase-4 inhibitor.{29490} INT-777 increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity.{29490} It also stimulates insulin secretion in pancreatic β cells, reduces inflammation and inhibits atherosclerosis in mice, and promotes chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cells.{29487,29489,29486}

产品描述

An agonist of TGR5 (EC50 = 0.82 µM); stimulates the secretion of GLP-1 in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a DPP4 inhibitor; increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity

保存建议

建议您在收到开曼生物品牌的INT-777 (500 ug)产品后置于-20℃保存.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.