（5Z）-7-氧玉米醇

中文名称

（5Z）-7-氧玉米醇

英文名字

(5Z)-7-Oxo Zeaenol

供应商

开曼生物

产品货号

17459-1

产品报价

￥1425.6/1mg

产品说明书

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购买方式

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产品新闻

背景资料

Transforming growth factor-β-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxo zeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1).{28252} In cells, (5Z)-7-oxo zeaenol is reported to irreversibly block IL-1-induced activation of TAK1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM.{28252} (5Z)-7-Oxo zeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation.{28252} This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.{28253}

产品描述

A natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein, TAB1); irreversibly blocks IL-1-induced activation of TAK1, NF-κB, and JNK/p38 (IC50s = 65-83 nM) and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro

保存建议

建议您在收到开曼生物品牌的L-783,279; FR148083; LL-Z 1640-2 (CAS 253863-19-3) (1 mg)产品后置于-20℃保存.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.