重组人音猬因子

中文名称

【SHH】重组人音猬因子

英文名字

Recombinant Human Sonic HedgeHog

供应商

ProSpec

产品货号

CYT-676

产品报价

￥800/5ug   ￥2080/25ug   ￥40250/1mg

产品说明书

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购买方式

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产品新闻

背景资料

Recombinant Human Sonic Hedgehog is part of a small group of secreted proteins that are vital for development in both vertebrates and invertebrates. 3 mammalian hedgehog genes （sonic，desert，Indian） share about 60% homology. The Human Sonic Hedgehog is 99% homologous to the mouse gene. Sonic HedgeHog is a protein that is vital in guding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube，the anterior-posterior limb axis，and the ventral somites. Sonic HedgeHog binds to the patched receptor，which functions in association with smoothened，to activate the transcription of target genes. In the absence of sonic HedgeHog，patched receptor represses the constitutive signaling activity of smoothened. Sonic HedgeHog also regulates another factor，the gli oncogene. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites，and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Sonic HedgeHog exhibits both floor plate- and motor neuron-inducing activity. Mutations in a long-range Sonic HedgeHog enhancer located in an intron of the limb region 1 gene result in preaxial polydactyly.

序列

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来源宿主

大肠杆菌中重组表达

溶解建议

提供的人音猬因子（SHH）产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml人音猬因子（SHH）的10mM 磷酸钠缓冲液（pH 7.5）中冻干产生的.我们建议加无菌的水以配制工作储存液到0.1-0.5mg/ml，后继实验过程中可根据实验要求进一步稀释.

保存建议

人音猬因子（SHH）在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延长保存时间，建议分装后置于-18℃冻存.请避免反复冻融.

其他

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。