5-氯-2-（4-氟苯氧基）苯甲酰基]氨基]乙基

中文名称

RQ-00015986; 4-[（1S）-1-[[5-氯-2-（4-氟苯氧基）苯甲酰基]氨基]乙基]-苯甲酸

英文名字

RQ-00015986; 4-[(1S)-1-[[5-chloro-2-(4-fluorophenoxy)benzoyl]amino]ethyl]-benzoic acid

供应商

开曼生物

产品货号

10010428-10

产品报价

￥677.6/10mg

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis.{16772,16773,16619} CJ-42794 is a selective antagonist of EP4 (Ki = 3.16 nM) that less potently binds EP2 (Ki = 631 nM) and has no affinity for EP1 or EP3.{14996,26030} It has minimal effect on numerous other receptors, enzymes, or channels.{26030} Unlike general inhibitors of PGE2 synthesis, CJ-42794 does not cause damage to rat gastrointestinal mucosa.{14996} Instead, it delays the healing of gastric ulcers in mice and rats, suppressing the upregulation of VEGF expression and angiogenesis.{26032} CJ-42794 blocks pain and inflammation in rat models of arthritis as well as gastric tumorigenesis in mice.{25895,26031}

产品描述

A selective antagonist of EP4 (Ki = 3.2 nM) that less potently binds EP2 (Ki = 630 nM) and has no affinity for EP1 or EP3; delays the healing of gastric ulcers, suppressing the upregulation of VEGF expression and angiogenesis; blocks pain and inflammation in rat models of arthritis and gastric tumorigenesis in mice

保存建议

建议您在收到开曼生物品牌的CJ-42794 (10 mg)产品后置于-20度保存，产品有效期为730天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.