帕唑帕尼

CAS :444731-52-6

Formula: C₂₁H₂₃N₇O₂S

Synonyms: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;GW 786034;Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-;Votrient;

Molecular Weight: 437.52

Boiling Point: 728.814 °C at 760 mmHg

Flash Point: 394.572 °C

Appearance: White powder

Assay: >99.0%

Exterior: White or off white crystal powder

Package: Aluminum bag

Storage: Room temperature

Application: Pazopanib, with its trade name of Votrient, is one kind of potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. For being one oral angiogenesis inhibitor targeting VEGFR and PDGFR, Pazopanib has been approved for renal cell carcinoma and soft tissue sarcoma. What's more, Pazopanib may also be active in ovarian cancer, and pazopanib also appears effective in the treatment of non-small cell lung carcinoma.