盐酸西替利嗪

进口原料盐酸西替利嗪83881-52-1供应

进口原料盐酸西替利嗪83881-52-1供应

进口原料盐酸西替利嗪83881-52-1供应

中文名称:盐酸西替利嗪中文同义词:西替利嗪盐酸盐;盐酸西替利嗪,一种选择性组胺H1受体拮抗剂;盐酸西替立嗪;(+/-)-2-[2-[4-[(4-氯苯基)苯甲基]-1-哌嗪基]乙氧基]乙酸二盐酸盐;盐酸西替利嗪;盐酸西替利嗪(标准品);盐酸西替利嗪溶液,100PPM;盐酸西替利嗪1KG英文名称:Cetirizinehydrochloride英文同义词:(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)aceticaciddihydro;2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]aceticaciddihydrochloride;CetirizineHydrochloride(250mg);Alercet;Alerid;Cesta;Cetiriz;CetrakCAS号:83881-52-1分子式:C21H26Cl2N2O3分子量:425.35EINECS号:620-533-8相关类别:药物原料;中药对照品;标准品;原料;医药原料;小分子抑制剂;中间体;细胞信号和神经生物学;Intermediates&FineChemicals;Pharmaceuticals;原料药;细胞生物学;API;Aromatics,Heterocycles,Metabolites&Impurities,Pharmaceuticals,Intermediates&FineChemicals;DOPRAM;心脑血管类科研原料药;添加剂;原料;标准品-中药标准品;化工中间体工业原料;医药原料药;添加剂;有机化学;日用化学品;ActivePharmaceuticalIngredients;Histaminereceptor;Aromatics;Heterocycles;Metabolites&ImpuritiesMol文件:83881-52-1.mol盐酸西替利嗪性质熔点110-115°C储存条件2-8°C溶解度H2O:soluble5mg/mL,clear形态powder颜色whitetobeige水溶解性Solubleinwater,DMSO,ethanol,andmethanol.Merck14,2022InChIKeyPGLIUCLTXOYQMV-UHFFFAOYSA-NCAS数据库83881-52-1(CASDataBaseReference)EPA化学物质信息Aceticacid,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,hydrochloride(1:2)(83881-52-1)盐酸西替利嗪用途与合成方法抗过敏药盐酸西替利嗪是安他乐的羟基衍生物，是一种抗过敏药，是新一代H1受体拮抗剂，属第二代H1抗组胺药，无抗胆碱和抗5-羟色胺的作用，极少透过血脑屏障。对不同化学诱导性介质包括血管活性多肽、P物质及神经肽等和嗜酸性粒细胞趋化反应有抑制作用，口服见效快，作用强而持久。副作用轻微，表现为嗜睡、疲劳，表情淡漠、注意力不集中等，一般不必停药。临床上用于治疗季节性或常年性过敏性鼻炎、由过敏原引起的荨麻疹及皮肤瘙痒，用法用量：成人和12岁以上者每次10mg，儿童0.1～0.5mg/kg·d，每日1次。从2008年1月11日起，我国将盐酸西替利嗪由处方药转换为非处方药。在香港以治敏速的名字由葛兰素史克以非处方药发售。西替利嗪的有效成分旋西替利嗪是盐酸西替利嗪的光学异构体之一（左旋体）。ChemicalBookandy整理编辑。生物活性CetirizineDiHCl(UCBP071)是一种抗组胺剂。靶点TargetValueHistaminereceptor体外研究Cetirizine(>5μM)athigherconcentrationscanreducethereleaseofGM-CSFandIL-8fromA549cellsstimulatedwithIL-1β.Cetirizineexertsanti-inflammatoryeffectsbeyondhistamineH1-receptorantagonist[2].CellViabilityAssay[2]CellLine:HumanairwayepithelialcelllineA549.Concentration:0-10μM.IncubationTime:24h.Result:ThesurvivalofA549cellsincubatedwithvariousconcentrationsofcetirizine(0.1,1,2.5,5,and10μM)for24hourswereallhigherthan90%whencomparingwiththecontrolgroupbyMTTtest.Cetirizine,5and10μM,suppressedGM-CSFreleaseby70.71and61.55%,respectively.Preincubationwithcetirizine,10μM,suppressedtheIL-8secretionby75.04%.体内研究Cetirizine(20mg/kg,mice,orally)exertsitsanti-inflammatoryeffectsbyinhibitingMIFaswellasIL-8productioninmiceimmunizedandchallengedwithragweedpollen[3].AnimalModel:Male8-week-oldBALB/cmice(25-30g)immunizedandchallengedwithragweedpollen[3].Dosage:2or20mg/kg.Administration:Orally,dilutedinsterilewaterondays18,19,and20.Result:Theneutrophiliaat8handeosinophiliaat24hinducedbyragweedpollenextractperosweresignificantlyreducedinthemicetreatedwith20mg/kg.Thedosagewith2mg/kghadnoeffect.用途主要用于呼吸系统、皮肤和眼睛的过敏性疾病