TP-064

TP-064 is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC₅₀ <10 nM). TP-064 inhibits dimethylation of BAF155 (IC₅₀ of 340 nM) and MED12 (IC₅₀ of 43 nM). TP-064 is inactive against the other family members except for PRMT6 (IC₅₀ of 1.3 μM). TP-064 has anticancer activities.