扑热息痛

Paracetamol(  4-Acetamidophenol) Paracetamol

CAS No.: 103-90-2
Molecular formula: C8H9NO2
Molecular weight:  151.16
EINECS number: 203-157-5

Melting point 168-172 °C (lit.)
Boiling point 273.17°C (rough  estimate)
Storage conditions Store at RT
Uses Mainly used for fever  caused  by cold, headache and relieve mild to moderate pain, such as joint pain,  muscle  pain, neuralgia, migraine, dysmenorrhea, cancer pain and postoperative  analgesia. It can also be used in patients who are allergic to aspirin,  intolerant or unsuitable for aspirin: patients with chickenpox, hemophilia and  other bleeding disorders (including those who have anticoagulant therapy), as  well as patients with mild peptic ulcer and gastritis.

Description:
Paracetamol, also known as acetaminophen or APAP, is a  medication used to treat pain and fever.It is typically used for mild to  moderate pain relief.Evidence for its use to relieve fever in children is  mixed.It is often sold in combination with other ingredients such as in many  cold medications.In combination with opioid pain medication, paracetamol is also  used for more severe pain such as cancer pain and pain after surgery. It is  typically used either by mouth or rectally but is also available  intravenously.Effects last between two and four hours.

Paracetamol is generally safe at recommended doses.Serious skin rashes may  rarely occur, and too high a dose can result in liver failure.It appears to be  safe during pregnancy and when breastfeeding.In those with liver disease, it may  still be used, but in lower doses.Paracetamol is classified as a mild  analgesic.It does not have significant anti-inflammatory activity and how it  works is not entirely clear.

Paracetamol was discovered in 1877.It is the most commonly used medication  for pain and fever in both the United States and Europe.It is on the World  Health Organization's List of Essential Medicines, the most effective and safe  medicines needed in a health system.Paracetamol is available as a generic  medication with trade names including Tylenol and Panadol among others.The  wholesale price in the developing world is less than 0.01 USD per dose.In the  United States it costs about 0.04 USD per dose.