芦荟大黄素

A7687
Sigma Aloe-emodin
≥95% (HPLC)

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Synonym: 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone
CAS Number: 481-72-1
Linear Formula: C15H10O5
Molecular Weight: 270.24
Beilstein Registry Number: 2059062
EC Number: 207-571-7

Description
Biochem/physiol Actions Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

性质
assay ≥95% (HPLC)
storage temp. 2-8°C