7.2 重组蛋白相关产品
重组蛋白是指利用DNA重组技术生产的蛋白质。重组蛋白可弥补体内功能蛋白缺陷，或者增加体内蛋白功能，达到治疗疾病目的，药物是重组蛋白发展的重要方向，在部分疾病治疗领域具有不可替代的重要作用。用于重组蛋白生产的宿主细胞可以来自细菌、哺乳动物细胞、昆虫和酵母。汇智泰康致力于为客户提供各种高纯度、低成本活性重组蛋白，包括细胞因子、生长因子、CD分子、免疫检查点等等。
产品应用：
Ø 免疫检查点 | Ø 抗体药物靶点 |
Ø CAR-T细胞治疗靶点 | Ø Fc受体 |
Ø 疫苗研发 | Ø 细胞因子 |
产品优势：
Ø 高活性、高纯度 | Ø 低成本 |
Ø 不同的大小，种类和标签 | Ø 货期短 |
产品类别：
7.2.1. 细胞因子(cytokine，CK)
是由多种组织细胞(主要为免疫细胞)所合成和分泌的小分子多肽或糖蛋白。细胞因子能介导细胞间的相互作用，具有多种生物学功能，如调节细胞生长、分化成熟、功能维持、调节免疫应答、参与炎症反应、创伤愈合和肿瘤消长等。
货号 | 名称 | 标签 | 规格 |
071A011 | Recombinant human IL-2 | His Tag | 100μg |
071A012 | Recombinant human IL-3 | His Tag | 25μg |
071A021 | Recombinant human IL-4 | His Tag | 100μg |
071A022 | Recombinant human IL-4 | His Tag | 25μg |
071A023 | Recombinant human IL-4 | human Fc | 100μg |
071A024 | Recombinant human IL-4 | human Fc | 25μg |
071A025 | Recombinant human IL-4 | mouse Fc | 100μg |
071A026 | Recombinant human IL-4 | mouse Fc | 25μg |
071A031 | Recombinant human IL-6 | His Tag | 100μg |
071A032 | Recombinant human IL-6 | His Tag | 25μg |
071A033 | Recombinant human IL-6 | human Fc | 100μg |
071A034 | Recombinant human IL-6 | human Fc | 25μg |
071A041 | Recombinant human IL-13 | His Tag | 100μg |
071A042 | Recombinant human IL-13 | His Tag | 25μg |
071A051 | Recombinant human IL-17A | His Tag | 100μg |
071A052 | Recombinant human IL-17A | His Tag | 25μg |
071A053 | Recombinant human IL-17A | human Fc | 100μg |
071A054 | Recombinant human IL-17A | human Fc | 25μg |
071A055 | Recombinant human IL-17A | mouse Fc | 100μg |
071A056 | Recombinant human IL-17A | mouse Fc | 25μg |
071A061 | Recombinant human TSLP | His Tag | 100μg |
071A062 | Recombinant human TSLP | His Tag | 25μg |
071A063 | Recombinant human TSLP | human Fc | 100μg |
071A064 | Recombinant human TSLP | human Fc | 25μg |
071A065 | Recombinant human TSLP | mouse Fc | 100μg |
071A066 | Recombinant human TSLP | mouse Fc | 25μg |
071A071 | Recombinant human IL-6R | His Tag | 100μg |
071A072 | Recombinant human IL-6R | His Tag | 25μg |
071A073 | Recombinant human IL-6R | human Fc | 100μg |
071A074 | Recombinant human IL-6R | human Fc | 25μg |
071A075 | Recombinant human IL-6R | mouse Fc | 100μg |
071A076 | Recombinant human IL-6R | mouse Fc | 25μg |
071A081 | Recombinant human IL-4R | His Tag | 100μg |
071A082 | Recombinant human IL-4R | His Tag | 25μg |
071A083 | Recombinant human IL-4R | human Fc | 100μg |
071A084 | Recombinant human IL-4R | human Fc | 25μg |
071A085 | Recombinant human IL-4R | mouse Fc | 100μg |
071A086 | Recombinant human IL-4R | mouse Fc | 25μg |
071A091 | Recombinant human IL7R | His Tag | 100μg |
071A092 | Recombinant human IL7R | His Tag | 25μg |
071A093 | Recombinant human IL7R | human Fc | 100μg |
071A094 | Recombinant human IL7R | human Fc | 25μg |
071A095 | Recombinant human IL7R | mouse Fc | 100μg |
071A096 | Recombinant human IL7R | mouse Fc | 25μg |
071A101 | Recombinant human IL-17RA | His Tag | 100μg |
071A102 | Recombinant human IL-17RA | His Tag | 25μg |
071A111 | Recombinant human TSLPR | His Tag | 100μg |
071A112 | Recombinant human TSLPR | His Tag | 25μg |
7.2.2. 生长因子（growth factor）
是 一类通过与特异的、高亲和的细胞膜受体结合，调节细胞生长与其他细胞功能等多效应的多肽类物质。其是由多种细胞分泌，作用于特定的靶细胞，调节细胞分裂、基质合成与组织分化的细胞因子。有胰岛素、表皮生长因子（EGF）、成纤细胞生长因子（fibroblast growth factor，FGF）、血小板来源增殖因子（platelet－derived growth factor，PDGF）以及生长激素释放抑制因子（somatostatin=SRIH）等。
货号 | 名称 | 标签 | 规格 |
072A011 | Recombinant human VEGF | His Tag | 100μg |
072A012 | Recombinant human VEGF | His Tag | 25μg |
072A013 | Recombinant human VEGF | human Fc | 100μg |
072A014 | Recombinant human VEGF | human Fc | 25μg |
072A015 | Recombinant human VEGF | mouse Fc | 100μg |
072A016 | Recombinant human VEGF | mouse Fc | 25μg |
072A021 | Recombinant human VEGFR | His Tag | 100μg |
072A022 | Recombinant human VEGFR | His Tag | 25μg |
072A023 | Recombinant human VEGFR | human Fc | 100μg |
072A024 | Recombinant human VEGFR | human Fc | 25μg |
072A025 | Recombinant human VEGFR | mouse Fc | 100μg |
072A026 | Recombinant human VEGFR | mouse Fc | 25μg |
7.2.3. CD分子
是不同谱系的白细胞在正常分化成熟的不同阶段及活化过程中，出现或消失的细胞表面标记。它们是细胞膜上的一类蛋白质或糖蛋白。在生理学上，CD分子有许多用途，通常用作细胞的重要受体或配体。 不仅可作为表面标志用于细胞的鉴定和分离，还广泛参与细胞的生长、成熟、分化、发育、迁移、激活。
货号 | 名称 | 标签 | 规格 |
073A011 | Recombinant human CD3 | His Tag | 100μg |
073A012 | Recombinant human CD3 | His Tag | 25μg |
073A021 | Recombinant human CD4 | His Tag | 100μg |
073A022 | Recombinant human CD4 | His Tag | 25μg |
073A031 | Recombinant human CD8 | His Tag | 100μg |
073A032 | Recombinant human CD8 | His Tag | 25μg |
073A041 | Recombinant human CD11 | His Tag | 100μg |
073A042 | Recombinant human CD11 | His Tag | 25μg |
073A051 | Recombinant human CD19 | His Tag | 100μg |
073A052 | Recombinant human CD19 | His Tag | 25μg |
073A061 | Recombinant human CD34 | His Tag | 100μg |
073A062 | Recombinant human CD34 | His Tag | 25μg |
073A071 | Recombinant human CD45 | His Tag | 100μg |
073A072 | Recombinant human CD45 | His Tag | 25μg |
073A081 | Recombinant human CD56 | His Tag | 100μg |
073A082 | Recombinant human CD56 | His Tag | 25μg |
073A091 | Recombinant human CD138 | His Tag | 100μg |
073A092 | Recombinant human CD138 | His Tag | 25μg |
073A101 | Recombinant human CD271 | His Tag | 100μg |
073A102 | Recombinant human CD271 | His Tag | 25μg |
073B111 | Recombinant mouse CD3 | His Tag | 100μg |
073B112 | Recombinant mouse CD3 | His Tag | 25μg |
073B121 | Recombinant mouse CD4 | His Tag | 100μg |
073B122 | Recombinant mouse CD4 | His Tag | 25μg |
073B131 | Recombinant mouse CD8 | His Tag | 100μg |
073B132 | Recombinant mouse CD8 | His Tag | 25μg |
073B141 | Recombinant mouse CD11B | His Tag | 100μg |
073B142 | Recombinant mouse CD11B | His Tag | 25μg |
073B151 | Recombinant mouse CD11C | His Tag | 100μg |
073B152 | Recombinant mouse CD11C | His Tag | 25μg |
073B161 | Recombinant mouse CD19 | His Tag | 100μg |
073B162 | Recombinant mouse CD19 | His Tag | 25μg |
073B171 | Recombinant mouse CD25 | His Tag | 100μg |
073B172 | Recombinant mouse CD25 | His Tag | 25μg |
073B181 | Recombinant mouse CD45 | His Tag | 100μg |
073B182 | Recombinant mouse CD45 | His Tag | 25μg |
073B191 | Recombinant mouse CD117 | His Tag | 100μg |
073B192 | Recombinant mouse CD117 | His Tag | 25μg |
7.2.4. 免疫检查点
一些存在人体免疫系统的共刺激和共抑制分子、蛋白，它们会传递信号；共刺激分子受体会提高机体的免疫反应用来对抗病原体，抑制性分子受体能够负向调节T细胞活力，用来保护过度的炎症反应。它们是癌症治疗中很值得关注的靶点，比如PD-1、PD-L1、B7、CD28、TIM、CD226家族。
重组蛋白表达系统分为原核表达和真核表达系统。原核表达主要是大肠杆菌表达系统，真核生物表达系统主要有酵母菌、哺乳动物细胞、昆虫细胞等表达系统。
货号 | 名称 | 标签 | 规格 |
074A011 | Recombinant human PD-1 | His Tag | 100μg |
074A012 | Recombinant human PD-1 | His Tag | 25μg |
074A013 | Recombinant human PD-1 | human Fc | 100μg |
074A014 | Recombinant human PD-1 | human Fc | 25μg |
074A015 | Recombinant human PD-1 | mouse Fc | 100μg |
074A016 | Recombinant human PD-1 | mouse Fc | 25μg |
074A021 | Recombinant human PD-L1 | His Tag | 100μg |
074A022 | Recombinant human PD-L1 | His Tag | 25μg |
074A023 | Recombinant human PD-L1 | human Fc | 100μg |
074A024 | Recombinant human PD-L1 | human Fc | 25μg |
074A025 | Recombinant human PD-L1 | mouse Fc | 100μg |
074A026 | Recombinant human PD-L1 | mouse Fc | 25μg |
074A031 | Recombinant human B7H3 | His Tag | 100μg |
074A032 | Recombinant human B7H3 | His Tag | 25μg |
074A033 | Recombinant human B7H3 | human Fc | 100μg |
074A034 | Recombinant human B7H3 | human Fc | 25μg |
074A035 | Recombinant human B7H3 | mouse Fc | 100μg |
074A036 | Recombinant human B7H3 | mouse Fc | 25μg |
7.2.5. SARS-cov2 相关蛋白
新型冠状病毒由双层脂质的囊膜组成，包含刺突蛋白（Spike protein，S）、包膜蛋白（Envelope protein，E）、膜蛋白（Membrane protein，M）以及核衣壳蛋白（Nucleoc-apsid protein，N）。其中S蛋白和N蛋白是其中最重要的用于检测的靶点蛋白。N蛋白一般种属特异性较高，通常作为检测的靶点，而表面的S蛋白特异性会低一些。S蛋白含有两个亚基，S1和S2，其中S1主要包含有受体结合区（receptor binding domain，RBD），负责识别细胞的受体，S2含有膜融合过程所需的基本元件。新型冠状病毒是通过识别ACE2蛋白进入人体细胞的。ACE2就像是“门把手”，病毒抓住它，从而打开了进入人体细胞的大门。
货号 | 名称 | 标签 | 规格 |
075A011 | S1 | His Tag | 100μg |
075A012 | S1 | His Tag | 25μg |
075A021 | ACE2 | His Tag | 100μg |
075A022 | ACE2 | His Tag | 25μg |
075A031 | RBD | His Tag | 100μg |
075A032 | RBD | His Tag | 25μg |
