普健生物（武汉）科技有限公司

链接：https://www.abinscience.cn/product/40/3737.html

名称：Anti-Human CD234/ACKR1 Antibody (2C3)

Accession号：Q16570

货号：HS835107

种属反应性：Human

宿主：Mouse

形式：Liquid

纯度：>95% as determined by SDS-PAGE.

克隆性：Monoclonal

同种型：IgG1, kappa

应用：FCM

用途范围：仅用于科研

储存：Use  a manual defrost freezer and avoid repeated freeze-thaw cycles. Store  at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C  long term.

产品介绍：Anti-Human  CD234/ACKR1 Antibody (2C3)  是武汉艾必赛生物技术有限公司推出的一款高特异性、高亲和力的小鼠源单克隆抗体。该抗体靶向人Fy糖蛋白/非典型趋化因子受体1  (ACKR1/CD234)，该靶点是重要的趋化因子“清除”受体和间日疟原虫的入侵受体，在调节炎症反应、细胞迁移及疟疾感染过程中发挥关键作用。本品克隆号为2C3，通过Protein  A/G从细胞培养上清中纯化，纯度超过95%，经严格验证适用于流式细胞术  (FCM)。其优异的特异性和灵敏度，使其成为研究炎症性疾病、造血调控、疟疾感染机制及相关药物开发的可靠工具试剂。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues. PMID: 28526034

Duffy Blood Group System. PMID: 35593798

A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1. PMID: 35803223

Strict tropism for CD71(+)/CD234(+) human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. PMID: 28698207

CD82/KAI1  Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through  Interaction with DARC-Expressing Macrophages. PMID: 26996598

KAI1(CD82)-DARC(CD234) axis in the stem cell niche. PMID: 27163847

Histone  deacetylase-mediated tumor microenvironment characteristics and  synergistic immunotherapy in gastric cancer. PMID: 37649598

Strict tropism for CD71(+)/CD234(+) human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. PMID: 28698207

Duffy Blood Group System. PMID: 35593798.

A subset of macrophages and monocytes in the mouse bone marrow express atypical chemokine receptor 1. PMID: 35803223

Rapidly freeze-dried human red blood cells for pre-transfusion alloantibody testing reagents. PMID: 33694280

CD82/KAI1  Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through  Interaction with DARC-Expressing Macrophages. PMID: 26996598

Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues. PMID: 28526034

The unhealthy attraction of Plasmodium vivax to reticulocytes expressing transferrin receptor 1 (CD71). PMID: 28414070

Bioaugmentation  of electrogenic halophiles in the treatment of pharmaceutical  industrial wastewater and energy production in microbial fuel cell under  saline condition. PMID: 34627818

ACKR1(hi)ECs Promote Aortic Dissection Through Adjusting Macrophage Behavior. PMID: 39692014

Multi-omics  analysis of human tendon adhesion reveals that ACKR1-regulated  macrophage migration is involved in regeneration. PMID: 38714649

Resolving the fibrotic niche of human liver cirrhosis at single-cell level. PMID: 31597160

Distinct  Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical  Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis.  PMID: 30446388

Prospects for targeting ACKR1 in cancer and other diseases. PMID: 37006247

CXCL12 Derived From ACKR1(+) Intraplaque Neovessels Mediates CD8(+) T Cell Recruitment in Human Atherosclerosis. PMID: 39993040

The Duffy antigen receptor for chemokines, ACKR1,- 'Jeanne DARC' of benign neutropenia. PMID: 30592023

PDPN+  cancer-associated fibroblasts enhance gastric cancer angiogenesis via  AKT/NF-kappaB activation and the CCL2-ACKR1 axis. PMID: 39764562

Ancestry, ACKR1 and leucopenia in patients with systemic lupus erythematosus. PMID: 36376015

Single-cell  transcriptomic analysis deciphers the inflammatory microenvironment  characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in  immune-related myocarditis. PMID: 40380233

Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles. PMID: 37153544

ACKR1 gene polymorphisms in Bombay blood group (O(h)) individuals of Indian origin. PMID: 39126827

The  chemokines CXCL8 and CXCL12: molecular and functional properties, role  in disease and efforts towards pharmacological intervention. PMID:  36725964

详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司

武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。

核心业务覆盖：
✅ 抗体产品（单抗、多抗、重组抗体等）
✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）
✅ 分子与细胞实验相关耗材
✅ 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
✅ 科研供应链整合与项目配套支持

武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。