Aliases :

CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2

Swissprot :

O14508

WB Predicted band size :

22 kDa

Host/Isotype :

Rabbit IgG

Antibody Type:

Primary antibody

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Species Reactivity:

Human, Mouse, Rat

Immunogen:

Fusion protein of human SOCS2

Formulation:

Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Description:

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor.

IHC

1/25-1/100

ELISA

1/1000-1/2000

The image is immunohistochemistry of paraffin-embedded Human brain tissue using P07608(SOCS2 Antibody) at dilution 1/40. (Original magnification: ×200)