武汉艾美捷科技有限公司

Jena bioscience--2-Thio-UTP：s、2UTP、2-硫代-UTP、2-硫尿苷-5'-三磷酸钠盐Cat. No. Amount

NU-1151S 10 µl (100 mM)

NU-1151L 5 x 10 µl (100 mM)

艾美捷2-Thio-UTP：

货号：NU-1151L

运输：使用凝胶包装运输

储存条件：需在-20°C下储存，可以短期（累计不超过1周）暴露在室温下。

保质期：自交货日期起12个月

分子式：C9H15N2O14P3S（游离酸）

分子量：500.21 g/mol（游离酸）

精确质量：499.95 g/mol（游离酸）

CAS号：35763-29-2

纯度：≥ 95%（高效液相色谱法）

形态：水溶液

颜色：无色至微黄

浓度：100 mM - 110 mM

pH值：7.5 ±0.5

光谱特性：最大吸收波长274 nm，摩尔吸光系数14.2 L mmol^-1 cm^-1（Tris-HCl pH 7.5）

特定配体：

用于嘌呤能受体的配体：

在P2Y2受体上具有强效和选择性的激动剂[1,2,3,4]

相关产品：

高产T7 RNA合成试剂盒，#RNT-101

2-Thio-UTP参考文献：

[1] Higgins et al. (2014) Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes. Mediators Inflamm. 293925.

[2] Zizzo M. et al. (2012) Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. Purinergic Signal. 8 (2):275.

[3] Ko et al. (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg. Med. Chem. 16 (12):6319.

[4] El-Tayeb et al. (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J. Med. Chem. 49 (24):7076.

Kormann et al. (2011) Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nature Biotechnology 29:154.

Warren et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7 (5):618

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